King James Bible Dictionary

A cluster of stars, or stars which appear to be near each other in the heavens, and which astronomers have reduced to certain figures (as the "Great Bear," the "Bull," etc.) for the sake of classification and of memory. In Isaiah 13:10, where this word only occurs, it is the rendering of the Hebrew kesil, i.e., "fool." This was the Hebrew name of the constellation Orion (Job 9:9; 38:31), a constellation which represented Nimrod, the symbol of folly and impiety. The word some interpret by "the giant" in this place, "some heaven-daring rebel who was chained to the sky for his impiety."

CONSTELLATION, noun

1. A cluster of fixed stars; an asterism; a number of stars which appear as if situated near each other in the heavens, and are considered as forming a particular division. The constellations are reduced mostly to the figures of certain animals or other known things, as the bear, the bull, the ram, the balance, etc.

For the stars of heaven, and the constellations thereof, shall not give their light. Isaiah 13:10.

2. An assemblage of splendors or excellencies.

General references
Isaiah 13:10

The serpent
Job 26:13

Orion
Job 9:9; Amos 5:8
Astronomy